A Outline of Minamata Disease
3. Pathological Changes of Methylmercury Poisoning in the Nervous System

Adverse effects to nervous system caused by methylmercury

Preferential sites in the nervous system for pathological changes (red color areas).The lesions show characteristic signs and symptoms in Minamata disease.

1. Gait disturbance, loss of balance (ataxia), speech disturbance (Dysarthria)

2. Sight disturbance of peripheral areas in the visual fields (constriction of visual fields)

3. Stereo anesthesia (Disturbance of sensation)

4. Muscle weakness, muscle cramp (disturbance of movement)

5. Hardness of hearing (hearing disturbance)

6. Disturbance of sense of pain, touch or temperature (Disturbance of sensation)