Q1: When did Minamata disease occur?

A1: The first case of Minamata disease was reported in 1956.

Commentary:
Officially, two sisters aged 5 and 2 living in Minamata City were the first patients.
They had dyskinesia and generalized convulsions, as well as symptoms such as dystonia of their hands and feet and sudden fits of screaming.
Actually, some patients seemed to have appeared earlier, and out of 54 patients identified in that year, 17 had already died by the time the sisters became ill.